99499威尼斯(中国·WWW认证)游戏内容-Macau App Station

产品中心

Cleaved-Factor XII HC (R372) rabbit pAb
一键复制产品信息
ES1060
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
下载说明 ①

Overview

Product name: Cleaved-Factor XII HC (R372) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: F12; Coagulation factor XII; Hageman factor; HAF
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human FA12. AA range:323-372
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 41kD
GeneID: 2161
Human Swiss-Prot No: P00748
Cellular localization: Secreted.
Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
关闭

在线咨询

Online consultation

  • 在线咨询
  • 技术支持

关注微信公众号

微信扫一扫立即咨询

微信电脑端咨询

微信扫一扫立即咨询

微信电脑端咨询
关闭
Baidu
sogou