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EGFR (phospho Tyr1197) rabbit pAb

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ES1303

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

Product name:	EGFR (phospho Tyr1197) rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Source:	Rabbit
Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1197. AA range:1161-1210
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	175kD
GeneID:	1956
Human Swiss-Prot No:	P00533
Cellular localization:	Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.
Background:	The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],

Western Blot analysis of various cells using Phospho-EGFR (Y1197) Polyclonal Antibody diluted at 1:1000
Western Blot analysis of A431 cells using Phospho-EGFR (Y1197) Polyclonal Antibody diluted at 1:1000
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using EGFR (Phospho-Tyr1197) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from A431 cells treated with EGF 40 muM 10', using EGFR (Phospho-Tyr1197) Antibody. The lane on the left is blocked with the phospho peptide.

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