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ERK 1/2 (phospho Thr202) rabbit pAb

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ES1308

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

Product name:	ERK 1/2 (phospho Thr202) rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p
Source:	Rabbit
Dilutions:	IF: 1:50-200 WB 1:500-2000, IHC 1:50-300 IHC 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human p44/42 MAP Kinase around the phosphorylation site of Thr202. AA range:169-218
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	44+42kD
GeneID:	5595/5594
Human Swiss-Prot No:	P27361/P28482
Cellular localization:	Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .
Background:	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],

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